BIO-250 Idol 2019 1st place: Drippin' in Domains!

BIO-250 Idol 2019 Submission
Kayla DeBeVoise, Ayris Izmirli, LeeAnn Nguyen

The perfect protein song doesn't exist--
Lyrics (Made by Kayla):

[Intro]
Acid chain (chain)
Phenylalanine (F)
Valine, Glycine, Alanine (Ala)
Tryptophan nonpolar
Methionine and Cysteine
Proline and Isoleucine (one more left)
Leu to finish,  Leucine’s our last one (one)
Amino acid side chain’s halfway done (done)
Nonpolar to polar now were uncharged polar chains 
Glutamine and Serine, Tyrosine Asparagine Threonine
Hit the positive and lean
Arginine, Lysine R, K (R, K), Histidine (histidine)
Aspartic Acid negative Glutamic Acid OWWW

[Verse 1]
Ooo they look good on the backbone
There’s a reason why they bind N to C (terminus)
Yeah polar goes on the outside
And nonpolar’s hydrophobic you see!

[Pre Chorus]
When I refold with you
(When I refold with you)
I watch the structure change
(Watch the structure change)
What that function do?
(What that function do)
No my domains don’t play (NO)
Blame it on my ɑ helix
Blame it on my β sheets
Hydrogen bonds on sight, that’s right

[Chorus]
We out here drippin’ in domains
Polypeptide chains
Out here drippin’ in domains
You know it you know it
out here drippin’ in domains
Polypeptide chains
Out here drippin’ in domains
You know it you know it

[Verse 2]
Now sort it out for me baby (Sort it out now)
Cuz these dimers gettin’ out of control (NO CONTROL) (Yeah-ah)
Quaternary structures made of two or more
These proteins all have a goal 

[Pre Chorus]
When I refold with you
(When I refold with you)
I watch the structure change
(Watch the structure change)
What that function do?
(what that function do)
No my domains don’t play (NO)
Blame it on my ɑ helix
Blame it on my β sheets
Hydrogen bonds on sight, that’s right

[Chorus]
We out here drippin’ in domains
Polypeptide chains
Out here drippin’ in domains
You know it you know it
out here drippin’ in domains
Polypeptide chains
Out here drippin’ in domains
You know it you know it

[Bridge]
Proteins grab your ligands if your ligands’ size
Fits inside the active binding site
Ligands be selective so we’ll do this right (do this right)
If you have functions on your mind 
(scream)

[Rap Part 2]
Yeah we gotta turn it on gotta turn it on
Don’t it feel so good to be active (Ayy)
Yeah we gotta turn it on gotta turn it on 
(Yeah we gotta turn it on)
Yeah we gotta turn it on gotta turn it on
Don’t it feel so good to be active (Hey hey) 
Yeah we gotta turn it on gotta turn it on (Feels so good when youuu~)

[Chorus]
We out here drippin’ in domains [Drippin in domains] (We drippin’ on them)
Polypeptide chains
Out here drippin’ in domains
You know it you know it (You know)
out here drippin’ in domains (Drippin’ in domains with my dimers)
Polypeptide chains
Out here drippin’ in domains
You know it you know it (yeah you know we gotta add it on)

[Outro]
Yeah we gotta add it on gotta add it on 
Those low free energy states 
Yeah we gotta add it on gotta add it on
You know it you know it (OO)
Yeah we gotta add it on gotta add it on (Yeah we got it)
Those low free energy states (Those low free energy states baby)
Yeah we gotta add it on gotta add it on
You know it you know it.

Dancing Clown: LeeAnn Nguyen
Rapping Clown: Ayris Izmirli
Vocal Clown: Kayla DeBeVoise

Special thanks to 
- Dr. J Miller for letting us film in the laboratory
- Robert for giving us micropipette tips
- KJ for loaning the microphone
- Our lopsided tri-pod affectionately named "Bruno"
- Makayla Rico for playing the best Dunaway :-)

Domains!